So I thought this might be a interesting discussion topic since it is something that I am just starting to research and make changes to.
So from what I have read so far on certain servers it is either recommended to disable it outright or set exclusions for process and file paths. So for our file server (which has no Internet Access) I have disabled read & rename but left it on for write which has improved our performance on the server drastically. On our Exchange 2010 server (still no Internet access) I have disabled it outright while I get the exclusions up and running. For our SQL servers I am looking at disabling read & rename and toying with write but I am still researching best practices for a MS SQL server and A/V's.
So the question is, what have you done in your environment?
*edit*
Saw this XKCD comic which fits right in...
![Laughing :lol:](./images/smilies/icon_lol.gif)
![Image](http://imgs.xkcd.com/comics/voting_machines.png)